4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
| 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase | |||||||
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| Identifiers | |||||||
| EC number | 2.7.1.148 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) is an enzyme that catalyzes the chemical reaction
- ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Thus, the two substrates of this enzyme are ATP and 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, whereas its two products are ADP and 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase. This enzyme is also called CDP-ME kinase. This enzyme participates in biosynthesis of steroids.
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1OJ4, 1UEK, 2V2Q, 2V2V, 2V2Z, 2V34, and 2V8P.
References
- Fellermeier M, Sagner S, Zenk MH, Bacher A, Eisenreich W (2000). "Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-d-erythritol". Proc. Natl. Acad. Sci. U. S. A. 97 (3): 1062–7. doi:10.1073/pnas.97.3.1062. PMC 15522. PMID 10655484. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15522.
- Seto H (2000). "Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase". Tetrahedron Lett. 41 (16): 2925–2928. doi:10.1016/S0040-4039(00)00295-1.
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